These included initial proteinuria of more than 1g/d, hypertension, renal impairment (eGFR <60mL/min), hypoproteinemia (serum albumin <35 g/L), hyperuricemia (serum uric acid >420μmol/L), Yang-deficiency BC, and blood-stasis BC at the time of renal biopsy. The gene discussed is ALB; the disease is Hypertension.