TNF and neuropathic pain: The pathogenesis of neuropathic pain is characterized by neuroinflammation induced activation of immune cells and increased production of several inflammatory mediators, predominantly tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-33 (IL-33) [3–5], which play an important part in the development of neuropathic pain [6–8].