In addition, indomethacin is known to inhibit PGE234 and prostaglandin F2α (PGF2α) synthesis35, and antagonizing the PGE2 receptor subtype 4 (EP4) and PGF2α receptor (FP) have been shown to attenuate aortic dissection36 and aneurysm in mice37, respectively. The gene discussed is PTGER4; the disease is aneurysm.