One such pleiotropic gene is GSDMB: its low expression is associated with Crohn’s disease (CD) (PTWMR = 2.89 × 10−11), inflammatory bowel disease (PTWMR = 4.54 × 10−11), rheumatoid arthritis (RA) (PTWMR = 2.91 × 10−15), ulcerative colitis (UC) (PTWMR = 2.70 × 10−08), high-density lipoprotein cholesterol (PTWMR = 4.27 × 10−9), lymphocytes (PTWMR = 3.41 × 10−23) and mean platelet volume (PTWMR = 2.68 × 10−7). This evidence concerns the gene GSDMB and rheumatoid arthritis.