Considering that host factors (ethnicity, HIV infection) and mycobacterial factors (M. tuberculosis strain type, the site of disease) were strongly associated with the baseline CRP response in TB (39), we assessed the diagnostic efficiency of PPD-B-stimulated CRP using ROC analysis and found that CRP produced a better diagnostic outcome (AUC = 1) than PPD-B-stimulated AGP, unstimulated IL-8, and serum SAA in discriminating between bTBPCR-P and bTBPCR-N. This evidence concerns the gene CRP and HIV infectious disease.