CD8A and neoplasm: The density of CD3+CD4+ T cells in the tumor decreased in six of seven patients receiving 1.0 mg/kg IT1208 (Fig. 4c and Additional file 8: Table S2), while case 10 with PR showed a dramatic increase in the density of both CD3+CD8+ and CD3+CD4+ T cells in the tumor area (Fig. 4c).