Previously, we showed that administration of the anti-CD4 mAb had strong antitumor effects superior to those elicited by CD25+ Treg depletion or other immune checkpoint mAbs in B16F10, Colon 26, or Lewis lung carcinoma subcutaneous tumor models, which were completely reversed by CD8+ cell depletion [17]. The gene discussed is CD8A; the disease is neoplasm.