RHOC and colonic neoplasm: Inhibition of MRTF using a pharmacological inhibitor CCG-203971, led to decreased lung metastases in mice injected with the highly invasive, RhoC overexpressing melanoma cell line SK-Mel-147 [54].Bellovin et al. showed that Ets-1 increases RhoC expression in LIM1863 colon cancer cells, resulting in increased EMT and cell migration [24].