Several reports cumulatively suggest that RhoC regulates numerous steps of tumor progression, including proliferation [56, 88, 89], EMT [62, 63], invasion [61, 90, 91], intravasation [56, 92], extravasation [92], anoikis resistance [56], angiogenesis [56, 92] and metastasis [58, 61, 93]. The gene discussed is RHOC; the disease is neoplasm.