We present substantial in vitro and in vivo evidence to support that simultaneous utilization of PPP and low concentrations of ASP3026 to antagonize the activity of IGF-IR and NPM-ALK, respectively, could represent a superior strategy to treat the aggressive NPM-ALK+ T cell lymphoma than using higher concentrations of each of these two drugs alone. This evidence concerns the gene IGF1R and T-cell non-Hodgkin lymphoma.