We have previously noticed that the utilization of CHOP at the standard dose used in mice with subcutaneous xenografts of non-NPM-ALK+ T cell lymphoma [50, 51] was associated with pronounced toxicity that frequently caused early expiration of mice with systemic NPM-ALK+ T cell lymphoma [26]. The gene discussed is DDIT3; the disease is T-cell non-Hodgkin lymphoma.