MAPT and supranuclear palsy, progressive, 1: Tau has been implicated in numerous neurodegenerative diseases including Alzheimer’s disease (AD), frontotemporal dementia (FTD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick’s disease (PiD) and DLB, all of which are considered as either primary or secondary tauopathies [25, 82].