Tau has been implicated in numerous neurodegenerative diseases including Alzheimer’s disease (AD), frontotemporal dementia (FTD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Pick’s disease (PiD) and DLB, all of which are considered as either primary or secondary tauopathies [25, 82]. The gene discussed is MAPT; the disease is Alzheimer disease.