PRNP and neurodegenerative disease: In addition, different PRNP gene mutations have been suggested to play a potential role in clinical pictures mimicking other neurodegenerative diseases, such as Frontotemporal dementia (FTD) [33,34,35,36,37,38], Cerebral amyloid angiopathy (CAA) [5], familial neuropsychiatric illness [39], familial Alzheimer’s disease (AD) [40], and Huntington’s disease [41]; whereas the clinical picture may not be specific or confined to psychiatric features [32].