The polymorphisms in Nrf2, superoxide dismutase (SOD2), and glutathione peroxidase (GPX1) genes, individually, have been implicated previously in disease susceptibility or prognosis in end-stage renal disease (ESRD), CKD, or diabetic nephropathy patients [7,8,9,10,11]. The gene discussed is SOD2; the disease is stage 5 chronic kidney disease.