SNAI1 and lung cancer: In this context, the CtsL is involved in EMT, and its overexpression in lung cancer cells leads—via nuclear factor kappa B (NF-κB) signaling—to the upregulation of nuclear factors belonging to the snail family transcriptional repressors Snail and Slug, and the zinc finger e-box binding homeobox proteins ZEB1 and ZEB2 [138].