GSK3B and acute kidney injury: TDZD-8 (4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione), a pharmacological inhibitor of the powerful proapoptotic kinase GSK3β (glycogen synthase kinase 3 beta), reduces proximal tubular epithelial cell apoptosis and has positive influences on the kidney by inhibiting inflammation and increasing renal cell proliferation [178,179]: This makes it a rational option in human trials designed to prevent or treat AKI (Figure 3).