In Hodgkin’s Lymphoma (HL), which is characterized by constitutive AP-1 activity [89], AP-1 response elements were identified and demonstrate that cJun and JunB bind to an enhancer region of the PD-L1 promoter, facilitating the PD-L1 expression along with Epstein-Barr virus (EBV) infection [90]. Here, FOSB is linked to Hodgkins lymphoma.