Monoclonal antibodies targeting immune checkpoints (e.g., CTLA-4 and PD-1) have so far received approval from the Food and Drug Administration (and other regulatory authorities) for demonstrating dramatic clinical responses in patients with metastatic cancers, leading to substantial improvement of their overall survival (OS) across diverse histological types and genetics of neoplastic diseases [2,3]. This evidence concerns the gene PDCD1 and neoplasm.