SPINK1 and cervical squamous intraepithelial neoplasia: However, our results showed that the synonymous/non-synonymous mutations (Ka/Ks) ratio of the miR319-target and non-miR319-target TCP genes in the CIN clade were lower than 1.0 (Table S4), and there was no obvious difference between them, although the miR319-target genes showed relatively lower selective pressure.