SNP rs738409 in the PNPLA3 gene is strongly associated with the alcoholic hepatitis [29,30], alcoholic cirrhosis [31,32], hepatocellular carcinoma (HCC) and reduced transplantation-free survival [32,33,34], as well as non-alcoholic fatty liver disease (NAFLD) [27,35]. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.