We first confirmed that Sirt1 and Pgc-1α mRNA levels were elevated in a quick fashion from 1 to 6 h, and SIRT1 and PGC-1α expressions were also quickly activated from 1 h and lasted at least 48 h with, peaking levels at 3 h (SIRT1) and 6 h (PGC-1α) after KA induction of status epilepticus in the hippocampus. Here, PPARGC1A is linked to status epilepticus.