SIRT1 and status epilepticus: These effects affect mitochondrial biogenesis, which showed a decreased content of mitochondrial protein COX1 (Figure 4E) and mtDNA (Figure 4F) in rats that received pre-treatment of Sirt1 antisense ODN, and 24 h after induction of experimental status epilepticus when compared with the sham-control, sense ODN, and scrambled ODN groups.