SIRT1 and status epilepticus: After pre-treatment with Sirt1 antisense ODN (1 nmol) into the bilateral CA3 subfields 24 h before KA-induced status epilepticus, Western blot analysis revealed a reduction in the NRF1 protein level in hippocampal CA3 neurons 6 h after KA treatment when compared with sense and scrambled ODN for Sirt1 (Figure 4A).