Otherwise, increased immunoreactivity for NRF1 was present in the nucleus of CA3 neurons that were immunoreactive to NeuN at 6 h after the microinjection of KA into the hippocampus in animals that received a pre-treatment of sense (Figure 4C-g,h,i) or scrambled (Figure 4C-j,k,l) ODN for Sirt1. Moreover, a decrease in the augmented immunoreactivity for NRF1 detected at 6 h after experimental status epilepticus was found in the hippocampal CA3 neurons (Figure 4C-d,e,f) in animals that were pre-treated with Sirt1 antisense ODN (1 nmoL) into the bilateral hippocampal CA3 area. Here, SIRT1 is linked to status epilepticus.