Increased extent of neuronal damage with Sirt1 antisense ODN treatment were demonstrated in the hippocampal CA3 subfield in both qualitative (Figure 5D) and quantitative (Figure 5E) analysis of DNA fragmentation, an index for apoptosis, seven days after the induction of status epilepticus when compared with the sham-control, sense ODN, and scrambled ODN groups. This evidence concerns the gene SIRT1 and status epilepticus.