Otherwise, PGC-1α-positive cell was apparently reduced in the hippocampal CA3 neurons 6 h after KA-induced status epilepticus in animals with pre-treated microinjection of Sirt1 antisense ODN (1 nmoL) into the bilateral hippocampal CA3 field (Figure 3E-d,e,f). The gene discussed is SIRT1; the disease is status epilepticus.