In keratoconus, a disease characterized by irregular astigmatism resulting in significant visual impairment, LOXL3 expression is downregulated, as well as LOXL2 and LOXL4 expression, suggesting that LOX members may be involved in keratoconus pathogenesis (Figure 5c) [16]. The gene discussed is LOXL3; the disease is keratoconus.