In addition, its expression was increased in acute coronary syndromes and associated with the intercellular adhesion molecule 1 (ICAM-1).30 NF-κB inhibition in endothelial cells resulted in reduced development of atherosclerosis and was correlated with reduced expression of pro-inflammatory cytokines, chemokines and adhesion molecules in the aortas of mice fed with cholesterol-rich diet.31 This evidence concerns the gene NFKB1 and acute coronary syndrome.