Beyond the criteria anti-phospholipid antibodies (aPL) aCL and aβ2-GPI, aPL against several other anionic phospholipids (PLs) (e.g., phosphatidic acid, phosphatidyl-serine, -glycerol, -inositol), neutral PL (e.g., phosphatidyl-choline,–ethanolamine), and PL-binding proteins (e.g., annexin V, prothrombin) have been observed in APS [4, 5]. This evidence concerns the gene ACLY and autoimmune polyendocrinopathy.