RHOA and escherichia coli infection: Furthermore, to detect the primary KEGG pathways in the two groups (RhoA high and low), we performed GSEA and found that samples with high levels of RhoA were enriched with genes mainly involved in the lysosome, pathogenic Escherichia coli infection, purine metabolism and pyrimidine metabolism pathways (Figure 5D, left part), while those with low levels of RhoA had predominant genes involved in the hedgehog signaling pathway, linoleic acid metabolism, olfactory transduction and taste transduction (Figure 5D, right part).