KDR and atherosclerosis: First, pre‐clinical studies proved that the minor allele of rs2071559 polymorphism (−604 T > C) could lead to decreased transcription activity of VEGFR2, whereas the minor alleles of rs1870377 (+1719A > T) and rs2305948 (+1192G > A) polymorphisms were associated with reduced binding affinity of VEGFR2. 17 So theoretically, it is possible that these three functional genetic variations may impact biological function of VEGFR2 and VEGF, and ultimately influence individual susceptibility to ASCVD.