The VEGFR2 rs1870377 (dominant comparison: 0.81 (0.73‐0.89), I2 = 56%; recessive comparison: 1.40 (1.25‐1.57), I2 = 34%; allele comparison: 0.81 (0.76‐0.87), I2 = 0%), rs2071559 (dominant comparison: 0.83 (0.76‐0.91), I2 = 0%; recessive comparison: 1.22 (1.07‐1.38), I2 = 0%; allele comparison: 0.86 (0.81‐0.92), I2 = 0%) and rs2305948 (dominant comparison: 0.79 (0.72‐0.87), I2 = 25%; recessive comparison: 1.44 (1.08‐1.92), I2 = 60%; allele comparison: 0.79 (0.68‐0.92), I2 = 73%) polymorphisms were all found to be significantly associated with susceptibility to ASCVD in general population. Here, KDR is linked to atherosclerosis.