Previous studies have shown that higher CD152 and TIM-3 levels indicate a lymphocyte-inflamed tumor microenvironment,29,30 and SDF-1α may induce migration of monocytes, which may be correlated with the response to ICB.31,32 However, none of the ROC curves in this study had good sensitivity or specificity. This evidence concerns the gene HAVCR2 and neoplasm.