BDNF and esophageal squamous cell carcinoma: However, early change in BDNF levels did not distinguish responders from nonresponders among patients with ESCC or CRC (ESCC: −5.07% [95% CI, −51.62% to 41.49%] vs −10.66% [95% CI, −31.88% to 10.56%]; P = .75; CRC: 40.53% [95% CI, −5.55% to 86.61%] vs −4.65% [95% CI, −49.47% to 40.17%]; P = .14) (eFigure 5G and eFigure 5H in the Supplement).