LncRNAs have previously been shown to modulate cell cycle, primarily in cancer cell lines.40,41 Additionally, lncRNAs, such as smooth muscle and endothelial cell-enriched migration/differentiation-associated lncRNA and myocardin-induced smooth muscle lncRNA, inducer of differentiation, have also been previously shown to be influential in cardiovascular diseases and essential in controlling the phenotypic switching of VSMCs to maintain their contractile phenotype (42, 43). This evidence concerns the gene MYOCD and cardiovascular disorder.