This may also be the case for CENPF, which is also ubiquitously expressed and shown to be multifunctional to control mitotic control, transcriptional regulation, and muscle cell differentiation.52 Intriguingly, increased levels of CENPF have also been previously associated with increased proliferation in malignant conditions31 and associated with a poor prognosis in human cancers.53,54 However, the mechanism by which increased CENPF results in increased proliferation is not entirely understood. Here, CENPF is linked to cancer.