Receiver operating characteristics curve analysis showed that the optimal cut-off value of Nesfatin-1 to predict hypertension was >1.8 ng/mL, with a specificity of 71.9% and a sensitivity of 96.7% [area under the curve=0.703; 95% confidence interval (CI): 0.577-0.809; p=0.002] (Figure 3). This evidence concerns the gene NUCB2 and Hypertension.