Our previous studies have shown that oridonin enhances the anticancer activity of NVP‐BEZ235 against NB cells through autophagy.13 And, it has also been proved that oridonin can also generate ROS to sensitize NB cells to TRAIL‐induced apoptosis.26 At present, we investigate the effects of oridonin on NB cells and further explore the detailed molecular mechanisms. This evidence concerns the gene TNFSF10 and neuroblastoma.