In addition, recombinant immune endotoxin or vaccines targeting MSLN could effectively inhibit the proliferation, invasion, and metastasis of pancreatic cancer cells in vivo and in vitro, which further clarifies the significance of MSLN as a CAR‐T target in PDAC treatment.23, 24 He et al generated a second‐generation CAR‐T that targeted MSLN using the piggyBac transposon system. The gene discussed is MSLN; the disease is pancreatic neoplasm.