CAR‐T cells, which are a type of CD4+/CD8+T cells, are also affected by the immunosuppressive network in the tumor microenvironment.34, 35 What's more, the biochemical characteristics of tumor stroma, including hypoxia, the lack of nutrition, and low pH, all disrupt the chemotaxis of CAR‐T cells and the resulting antitumor effects.36, 37 In addition, antigen modulation may occur after CAR‐T therapy due to the intratumoral heterogeneity, which also leads to CAR‐T dysfunction.38 The gene discussed is CD4; the disease is neoplasm.