GDF5 and bone disorder: It has been evident that GDF5 is important for normal skeletal, joint, and bone development (Settle Jr et al., 2003), as well as GDF5 mutations lead to various rare skeletal diseases (Faiyaz‐Ul‐Haque et al., 2002; Polinkovsky et al., 1997; Seemann et al., 2005; Thomas et al., 1997, 1996).