Studies documented that mutations in GDF5 lead to an increased risk of arthritis, short bones, and skeletal disorders (Dai et al., 2008; Lettre, 2017; Plett, Berdon, Cowles, Oklu, & Campbell, 2008; Rouault et al., 2010; Zhao et al., 2013). The gene discussed is GDF5; the disease is arthritic joint disease.