KCNC4 and Alzheimer disease: Indeed, our results suggest that the upregulation of KV3.4 channel subunits in astrocytes may be an early event in the AD brain, since we observed astrocytes accumulating Aβ and overexpressing KV3.4 subunits in cortex, hippocampus, and cerebellum of 6 month old Tg2576 mice (Boscia et al., 2017).