TUFT1 can regulate DUSP1 expression in our previous studies (13), therefore, we consider whether there is a link between TUFT1/Rac1 pathway and DUSP1 to regulate downstream MAPK pathways, or whether TUFT1 directly mediates DUSP1 bypass signal to regulate apoptosis and chemoresistance of BC cells. This evidence concerns the gene RAC1 and breast cancer.