APC and intestinal disorder: In another SB model of intestinal disease, Takeda et al. compared the candidate tumor drivers identified in tumors from mice with one of three predisposing mutations: KrasG12D/+, Smad4KO/+, or Trp53R172H/+ with a pooled list of candidate drivers identified in SB tumors from mice with somatic or germline Apc mutations (collectively referred to as Apc) (68, 78).