Again, while utilization of the Pten mouse strain introduced genetic variability between the two groups that is difficult to account for (the SB mice were crossed with the C;129S4-Ptentm1Hwu/J strain), investigators found 10/30 (33%) of candidate tumor drivers making up ≥2% of total reads in tumors from the high fat diet group to overlap with those identified in the Pten group. The gene discussed is PTEN; the disease is neoplasm.