Genetic data from human HCC samples corroborated gender-specific findings, as tumors with polysomy of chromosome 7 (the location of human EGFR) displayed elevated EGFR mRNA expression and were disproportionately male (33:1 male to female ratio in the polysomy 7 subclass vs. 2:1 ratio in all other subclasses of human HCC evaluated) (154). This evidence concerns the gene EGFR and hepatocellular carcinoma.