RECK and neoplasm: Altogether, 189 variants were discovered in RECK, of which stop gained (N = 1), frame shift (N = 1), and missense variants (N = 44) could lead to abnormal protein product and disrupt tumor suppressor function of gene RECK. Particularly, RECK is known to produce two proteins which have opposing effects, the shorter isoform of RECK leads to faster cell migration (38).