UCA1 and acute myeloid leukemia: Of note, UCA1 was first described in AML as a regulatory target gene of CEBPα-p30 (55)—the 30-kDa isoform that results from mutations in CEBPA. Hughes et al. showed that both wild-type CEBPα and the p30 protein bind the UCA1 promoter but produce opposite effects on UCA1 expression.