SPOCK1 and colorectal cancer: In addition, in a study of gastric cancer, SPOCK1 was found to promote the invasion and metastasis of gastric cancer through Slug-induced epithelial-mesenchymal transition (Chen et al., 2018), and knockdown of SPOCK1 in colorectal cancer could inhibit proliferation and invasion of cancer cells by suppressing the PI3K/Akt Pathway (Zhao et al., 2016).