In addition, Chung et al. (2008) found that abnormal methylation of the SPOCK2 gene was closely associated with PCa, breast cancer, and colon cancer by screening differential methylation genes, and it was deduced that screening for epigenetic inactivation of SPOCK2 could be used as a diagnostic marker for PCa (Verma, Patel & Verma, 2011). Here, SPOCK2 is linked to malignant colon neoplasm.