One of latest reports regarding TLRs variants in a group of patients with advanced and metastatic CRC indicated that TLR4 Asp299Gly, TLR4 Thr399Ile, TLR9 T1237C and T1486C and TLR2–196 to − 174 del/del homozygous genotypes were significantly associated with CRC. Here, TLR2 is linked to colorectal carcinoma.