STAT3 and Anxiety: Li et al. [62] suggested that Xiaoyao San can alleviate hippocampal neuronal injury and reverse effects measured using the hypertension labyrinth test, through activation of the TNF-α/Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) pathway in a rat model of chronic immobilization stress-induced anxiety.