B-1 cells are producers of a variety of molecules, such as IL-10, IL-3, and GM-CSF (Chousterman and Swirski, 2015), which are capable of exerting influence on other cell populations and thus may influence the susceptibility or resistance in models of infection (Minoprio et al., 1993; Popi et al., 2008; Arcanjo et al., 2017). This evidence concerns the gene CSF2 and infection.