This raises an interesting question, could the degree of cardiac dysfunction, due to variation in the percentage of cardiomyocytes that express Cxadr, result in the difference between embryonic lethality, as seen in CxadrΔ/Δ(f);TgTnnt2-Cre embryos, and cardiomyopathies like those exhibited in CxadrΔ/Δ(f);TgMyh6-Cre adult mice? Here, CXADR is linked to cardiomyopathy.