TRPC6 and pulmonary arterial hypertension: These facts prove that STS can be used to prevent AS and restenosis after PCI (Wu et al., 2014), and it helps to prevent the development of pulmonary arterial hypertension (PAH) by inhibiting the expression of canonical transient receptor potential (TRPC)1 and TRPC6, leading to normalized basal intracellular Ca2+ concentration ([Ca2+]i) and attenuated the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) (Wang et al., 2013a).