Furthermore, the activation of inflammatory signaling pathways, such as nuclear factor-κB (NF-κB), and several oxidative stress related factors, such as Kelch-like ECH-associated protein 1 (Keap1), NF-E2 p45-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1), are related to the severity of inflammation of AD (Seo et al., 2015; Sun et al., 2015). The gene discussed is HMOX1; the disease is Alzheimer disease.