Specific FTD-associated MAPT mutations have been shown to alter the aggregation, β-sheet propensity, isoform ratio and MT binding properties of the WT tau (Hong et al., 1998; Barghorn et al., 2000; von Bergen et al., 2001; Combs and Gamblin, 2012; Kaniyappan et al., 2017). Here, MAPT is linked to frontotemporal dementia.