Given that pathological tau can impair nucleocytoplasmic transport in AD brains and tau transgenic mice (Eftekharzadeh et al., 2018), and the overexpression of the N279K tau variant in a cell model is associated with increased nuclear localization (Ritter et al., 2018), the effect of tau on the protein synthesis machinery deserves further investigation. Here, MAPT is linked to Alzheimer disease.