Notably, in the case of tau, structurally distinct fibrillar assemblies from brain have recently been characterized in AD, Pick’s disease and chronic traumatic encephalopathy (CTE) strongly suggesting that distinct strains of propagating tau assemblies are contributing to different disease phenotypes in humans (Fitzpatrick et al., 2017; Falcon et al., 2018; Falcon et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.