Significantly, visualization of the PrP rods by tomography and the ensuing recognition of their basic architecture (Terry et al., 2016, 2019) now enables the structural features of the PrP rods to be readily seen in most published EM images of SAFs and prion rods from earlier studies, including those from CJD brain (Merz et al., 1984). Here, PRNP is linked to Creutzfeldt Jacob disease.