MAPT and neurodegenerative disease: Indeed various pathological proteins including Aβ peptides, α-synuclein and tau were shown to be able to adopt distinct strains with different molecular structures, which might be linked to phenotype diversities of the neurodegenerative diseases (Guo et al., 2013; Riek and Eisenberg, 2016; Goedert et al., 2017; Falcon et al., 2018; Peng et al., 2018a,b).