Indeed, our rodent stroke studies support this (Turner et al., 2006, 2011; Corrigan et al., 2012, 2016; Turner and Vink, 2012, 2014) and corroborates our recent work demonstrating the efficacy of NK1-r antagonist treatment in reducing ICP in an ovine model of permanent MCAO (Sorby-Adams et al., 2019). This evidence concerns the gene TACR1 and stroke disorder.