Earlier studies have established that reduced cell viability in curcumin-treated tumor cells was accompanied by the repression of signaling proteins such as NF-ƙB and Notch-1, blocking downstream genes like vascular endothelial growth factor (VEGF), Bcl2 and matrix metalloproteinase (Marquardt et al., 2015[25]; Mou et al., 2017[30]; Pavan et al., 2016[34]). Here, NOTCH1 is linked to neoplasm.