IL-1β is also considered as an important pro-inflammatory cytokine in the brain and plays a critical role in the progression of neuroinflammation, which is a well-known factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis (Lee et al., 2016[23]). This evidence concerns the gene IL1B and early-onset autosomal dominant Alzheimer disease.