TP53 and neoplasm: A major part of the network (Fig. 1c) relates to tumor suppressor activities mediated by transcription factors, particularly TP53. Mutations in several genes with transcriptional regulatory functions (i.e., the left side of Fig. 1c) are mutually exclusive (e.g., zf-C2H2 or zf-C2H6 with either P53 or EGF domains).