In melanoma 31% (146 out 462) of dysregulated genes in R3.50 mutated samples overlap with those of G-protein activating mutations (GNAQ p.Q209G.s3h2.3 and GNAI2 p.R179G.hfs2.2), indicating at least partial functional equivalence between these mutually exclusive mutation sets and moreover pointing to biological processes characteristic of more aggressive melanomas (e.g., thickening, loss of inhibitory endopeptidase activity [36], see Fig. S12a). Here, GNAI2 is linked to melanoma.