While other studies have described that the anti-tumor selectivity of CAP depends on the activation of p53 and ERK47,68, our data in SaOS-2 cells (P53 null)72 indicate that p53 (S46) is not related to PAM cytotoxicity (Fig. S2), while ERK is downregulated (Fig. 6). The gene discussed is TP53; the disease is neoplasm.