In accordance with these beneficial effects of apelin, in autosomal dominant polycystic kidney disease patients, a negative correlation between plasma apelin and TGFβ was found, while apelin was positively correlated to eGFR suggesting that although many similarities are observed between aging and CKD, the underlying mechanisms are different and do not present the same sensitivity to apelin treatment. The gene discussed is APLN; the disease is autosomal dominant polycystic kidney disease.