Given that syndecan-2 and MMP-7 are important regulators in colon carcinogenesis13,28,29 and we previously showed that the extracellular domain of syndecan-2 interacts with pro-MMP-7 to cooperatively regulate tumorigenic activities in human colon cancer cells, we herein further investigated the detailed structural basis of the interaction between the syndecan-2 extracellular domain and the pro-domain of MMP-7. This evidence concerns the gene SDC2 and colonic neoplasm.