MMP7 and cancer: Meanwhile, addition of the synthetic peptide (S2-P) reduced the syndecan-2-mediated anchorage-independent growth of HT-29 cells in parallel with its ability to reduce the interaction of syndecan-2 with pro-MMP-7 (Fig. 7E), suggesting that the ability of syndecan-2 to regulate cancer activity regulation is closely related to its interaction with pro-MMP-7.