As seen for other MMPs, increased MMP-7 regulates cancer progression and invasion through regulating the proteolytic degradation of ECM molecules (e.g., elastin, type IV collagen, fibronectin, vitronectin, aggrecan, and proteoglycan)11, and non-ECM molecules (e.g., β4 integrin, E-cadherin, FasL, proHB-EGF, and TNFα precursor)12. The gene discussed is CDH1; the disease is cancer.